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Significant challenges remain for its broad applicability as a potential curative therapy for human genetic diseases, mainly related to ensuring efficient and safe delivery to target tissues.
Emilio M. García-Tenorio, Mar Álvarez, Eva Richard et al.
· Methods in molecular biology · 0 citations
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This review systematically summarizes the key improvements and evolutionary progress in the prime editor design and its updated delivery systems, with a particular focus on innovative modifications that have successfully overcome technical barriers.
Shu-Ran Zhang, Leong Chang, Ya-Min Kong et al.
· Current Gene Therapy · 0 citations
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Sep 2026
Heidi Ledford
· Nature · 0 citations
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This review dissects the technological foundations and limiting factors of multiplex genome editing, focusing on guide RNA (gRNA) array engineering, delivery constraints, and scale‐dependent safety risks.
Lin-Li Wang, Yong-Bin Liu, Hong-Bing Han
· Animal Research and One Heal... · 0 citations
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A new generation of genome editors derived from mobile genetic elements is emerging to address both issues, particularly from the bacterial transposons and insertion sequences colloquially known as ‘jumping genes’.
Christopher Jin, J. Tree
· Microbiology Australia · 1 citation
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This review discusses about the mechanism followed by CRISPR CAS9 in gene editing and various other possible applications of CRISPR CAS9.
Amaan Hussain Gouri, Khushmanpreet Kaur, Abhishek Sharma et al.
· International Journal of Sci... · 0 citations
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