This review delineates CCT6A’s multifunctional roles in oncogenesis and immune-metabolic dysregulation, critically evaluates its biomarker potential, and proposes targeted therapeutic frameworks to refine precision medicine paradigms across diverse disease landscapes.
Abstract Hepatocellular carcinoma (HCC) is characterized by high malignancy and widespread drug resistance at advanced stages, posing formidable challenges in clinical diagnosis and treatment. Mitochondrial dysfunction is a core driver of HCC initiation and drug resistance. However, how its plasticity dynamically regul...
Si-Yu Zhao, Qian Liu, Jing Li et al.· Journal of Hepatocellular Ca...· 0 citations
Abstract Ribosomal protein S3 (RPS3) is an essential structural component of the 40S ribosomal subunit, yet growing evidence highlights crucial extraribosomal roles in genome maintenance, cell-cycle control, and immune signaling. Dysregulation of RPS3 contributes to diverse human disorders, including cancer, inflammato...
Joeline Dreik, M. Al Ali, Jalil Daher et al.· Bioscience Reports· 0 citations
Receptor-interacting protein kinase 1 (RIPK1) plays a pivotal role in regulating cell survival and death, thereby exerting complex and multifaceted functions in the initiation and progression of cancer. Its expression is frequently dysregulated across diverse malignancies and correlates strongly with poor prognosis, hi...
Jing-Yu Luo, Shu-Ya Song, Ze-Kun Li et al.· Cellular Signalling· 0 citations
Cancer progression is driven by coordinated dysregulation of signaling and gene-expression programs that sustain multiple hallmarks of malignancy. Eukaryotic initiation factor 4E (eIF4E) has emerged as an important determinant of this translational reprogramming by preferentially enhancing the synthesis of proteins tha...
Magdalene Eno Udobi, P. Effiong, Sumon Roy et al.· Critical reviews in oncology...· 0 citations
TXNL1 (thioredoxin-like protein 1), a member of the thioredoxin superfamily, integrates thioredoxin oxidoreductase activity with molecular chaperone function. Through its N-terminal TRX domain and C-terminal PITH domain, TXNL1 not only helps maintain cellular redox homeostasis but also prevents toxic aggregation of oxi...
Shan-Shan Wu, De-Yuan Li, Dong-Qiong Xiao· Frontiers in Cell and Develo...· 0 citations
This review examines the emerging role of SQLE as a potential metabolic-immune checkpoint, systematically integrating cutting-edge epitranscriptomic regulatory mechanisms published from 2024 to 2026, dissecting the full spectrum of SQLE-mediated immunosuppressive pathways, and conducting critical comparative analysis b...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
