Open access

Associations of proteomic and epigenetic aging clocks with Alzheimer's disease phenotypes: An exploratory analysis

Cindy David Sarmento G. Drouard T. Saari A. Aaltonen A. Heikkinen Mikaela Hukkanen T. Palviainen S. Herukka T. Kokkola S. Kärkkäinen A. Palotie V. Julkunen H. Runz J. Kaprio M. Ollikainen E. Vuoksimaa

Jul 2026 · Alzheimer's & Dementia · Vol 18 · 1 citation · 42 references

Medicine

TL;DR

The potential of plasma proteomic clocks in detecting AD‐related phenotypes and co‐morbidities possibly constitute confounding factors, compromising the performance of proteomic aging models is illustrated.

Abstract

Proteomic aging clocks detect disease‐related systemic and organ‐specific changes and are easily accessible by minimally invasive blood draws. However, their potential in Alzheimer's disease (AD) assessment remains unestablished.

DOI PubMed Semantic Scholar

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