SOX9 knockdown alleviates Aβ1‑42‑induced neuroinflammation by regulating microglial polarization via inactivation of the ASK1/JNK signaling pathway

Modulation of IKKβ deubiquitination dynamics by CYLD links microglia-neuron crosstalk to be involved in Alzheimer’s disease

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder with limited therapeutic options. Microglia-mediated neuroinflammation plays a critical role in its pathogenesis. Depending on the microenvironment, activated microglia can adopt either a pro-inflammatory or an anti-inflammatory phenotype. Previous...

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Findings uncover an OTUD7B‐STAT3 signaling axis that sustains microglial‐driven neuroinflammation and identify OTUD7B as a potential therapeutic target for mitigating neurodegenerative pathology in AD.

Integrative transcriptomic analysis reveals KLHL2 downregulation as a potential driver of microglial inflammation in Alzheimer’s disease via the WNK3/JNK/c-Jun axis

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by prominent neuroinflammation. Microglia, the resident immune cells of the central nervous system, play a key role in AD-associated neuroinflammation, yet the molecular mechanisms regulating their inflammatory activation remain incomple...

LncRNA UCA1 Aggravated Microglia-mediated Neuroinflammation After Traumatic Brain Injury by Targeting miR-708-5p.

Ginsenoside Rg1 Attenuates Neuroinflammation in Parkinson's Disease Models via Concomitant Modulation of Canonical and Noncanonical Wnt Pathways in Microglial M1/M2 Polarization.

Microglial-mediated neuroinflammation is a core driver of brain disorders. Thus, modulating microglial activity is a critical therapeutic goal. In this study, we explored how Ginsenoside Rg1 (Rg1) protects against the inflammation seen in Parkinson's disease (PD). Our experiments utilized MPTP-challenged mice and lipop...

miR-584-5p suppresses Aβ1-42-induced apoptosis in Alzheimer's disease cell model via targeting of HDAC1.