Salvianolic acid a alleviates myocardial ischemia-reperfusion injury in rats via SIRT1-mediated inhibition of oxidative stress and inflammation.

Isolinderalactone alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress through the SIRT1/IRE1α signaling pathway.

ILL attenuates HIRI by simultaneously elevating SIRT1 expression and activating its deacetylase function, thereby restraining IRE1α-dependent ERS and subsequent hepatic injury, highlighting ILL as a promising therapeutic candidate for the management of perioperative HIRI.

(S)-SA, a bioactive flavonoid from Dalbergiae Odoriferae Lignum, alleviates cerebral ischemia-reperfusion injury via SLC11A2-mediated ferroptosis inhibition.

BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) remains a major barrier to neurological recovery after ischemic stroke, and effective pharmacological interventions targeting upstream neurovascular unit mechanisms related to ferroptosis and blood-brain barrier (BBB) injury are limited. PURPOSE This study aimed...

Alleviation of hepatic ischemia-reperfusion injury by ginsenoside Rg5 and deoxyandrographolide through inhibition of SLC7A11/GPX4-mediated ferroptosis.

Shenfu Injection is a traditional Chinese medicine formulation widely used for cardiovascular and ischemic disorders. This study investigated the protective effects and underlying mechanisms of its bioactive constituents, ginsenoside Rg5 (Rg5) and deoxyandrographolide (DA), against hepatic ischemia-reperfusion injury (...

Ferulic acid attenuates acute ischemic cerebral injury by enhancing antioxidant capacity and modulating autophagy via the Nrf2 signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE Ferulic acid (FA), a key bioactive compound extracted from Angelica sinensis- traditionally used in herbal medicine, is now widely used as nutritional supplements and therapeutic agent for the management of cardiovascular diseases in which oxidative stress and autophagy dysregulation cont...

Ginsenoside Rc exerts protective effects against cerebral ischemia‒reperfusion injury by boosting the Nrf2 pathway through targeted activation of Sirt1.

Salvianolic Acid C Protects Against Hepatic Ischemia-Reperfusion Injury via Heat Shock Protein 90α-Mediated Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway.

Hepatic ischemia-reperfusion injury (HIRI) is a major challenge in liver surgery, and effective pharmacological interventions are lacking. Salvianolic acid C (SaC) has shown protective effects in various pathologies, but its role in HIRI remains unclear. This study investigated whether SaC protects against HIRI and elu...