Sep 2026· Journal of dermatology (Print)· 0 citations· 19 references
Medicine
TL;DR
CCL17 is a novel potential biomarker for PU pathogenesis and prognosis and demonstrated high clinical relevance in the patients with PU.
Abstract
Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this study, PU and normal tissues were collected from 24 patients with PU. An exploratory Olink Inflammation Panel analysis was performed to identify candidate differentially expressed proteins (DEPs) between PU and normal tissue samples from 16 of the 24 patients with PU. A total of 16 candidate DEPs were identified using an unadjusted p < 0.05 threshold between the two groups. Among them, CCL17 had the largest fold change and diagnostic potential with an optimal AUC value (0.75). In addition, CCL17, ANGPT1, FASLG, and VEGFA demonstrated high clinical relevance in the patients with PU. Immunohistochemistry and western blotting using PU tissues obtained from the remaining 8 patients confirmed the decreased expression of CCL17 in PU tissues. In conclusion, CCL17 is a novel potential biomarker for PU pathogenesis and prognosis.
BACKGROUND
Abnormal lipid metabolism plays a crucial role in diabetic foot ulcers (DFU). This study aims to systematically uncover the cell-specific mechanisms of lipid metabolism disorders in DFUs and screen for potential diagnostic biomarkers.
METHODS
Bulk and single-cell transcriptomic data related to DFUs were in...
Guang Zeng, Yi Huang, Jun-Sheng Hu et al.· Current Pharmaceutical Biote...· 0 citations
BACKGROUND Elucidating immune signals through well-defined cohorts of pediatric acute pancreatitis (AP) and chronic pancreatitis (CP) patients is critical. This study aimed to evaluate plasma chemokine and cytokine levels in pediatric participants with CP, compared with AP and healthy controls (HCs), to identify unique...
P. Farrell, Bomi Lee, Faizan Ahmed et al.· JCI Insight· 0 citations
Psoriasis is a long-term inflammatory skin disease that occurs when a person's genes are affected by some environmental triggers. The triggers are associated with immune dysregulation by complex inflammatory mechanisms, causing the typical pathological changes in the skin. This study aimed to investigate the role of T...
Zainab Dheyaa Ismael, S. J. Raisan· Adolescência e Saúde· 0 citations
Objective Endometriosis is a chronic inflammatory disorder lacking definitive laboratory diagnostic markers. Angiopoietin-like protein-4 (ANGPTL4) is a protein involved in the regulation of angiogenesis and inflammation. The aim of the present study was to evaluate serum and peritoneal fluid (PF) levels of ANGPTL4 to e...
Merve Didem Eşkin Tanrıverdi, Esin Merve Koç· Journal of the Turkish-Germa...· 0 citations
Clinical biomarkers showed a significant increase in all biomarkers that include white blood cell, red blood cell, neutrophil, lymphocyte, platelets, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), and clinical biomarkers showed a significant increase in all biomarkers.
Zahraa H. Khudhair, Sahar M. Hussein· Iraqi Journal of Science· 0 citations
In this retrospective case-control study, the relationship between new inflammatory markers and the development and stage progression of pressure ulcers (PUs) was evaluated in 1246 patients followed up for pressure ulcers. Participants' sociodemographic characteristics, presence and stages of pressure ulcers, and neutr...
Muhammed Enes Güngör, Adem Durmaz, Çagla Ozdemir et al.· Uluborlu Mesleki Bilimler De...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
