Programmed cell death in kidney disease: integrated crosstalk among ferroptosis, pyroptosis, apoptosis, and cuproptosis

Hub of life and death: Global regulation of ferroptosis by inter-organelle crosstalk

Ferroptosis is an iron-dependent form of programmed cell death defined by the lethal accumulation of lipid peroxides. Accumulating evidence indicates that ferroptosis plays a critical role in a wide range of pathological processes, including tumor progression, ischemia-reperfusion injury, and neurodegenerative diseases...

Metabolism-Gated Cell Death Switching in Myocardial Ischemia-Reperfusion Injury: From Regulated Death Networks to Precision Cardioprotection

Myocardial ischemia–reperfusion injury (MIRI) is driven by dynamic metabolic disturbances that extend beyond adenosine triphosphate depletion and encompass mitochondrial dysfunction, redox imbalance, calcium overload, iron dysregulation, lipid peroxidation, and inflammatory activation. These alterations regulate multip...

Regulated Cell Death at the Maternal-Fetal Interface in Preeclampsia: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, Autophagic Cell Death, and Cuproptosis - A Narrative Review

Abstract Preeclampsia is a pregnancy-specific multisystem disorder in which placental stress is translated into maternal endothelial dysfunction, hypertension, and end-organ injury. This narrative review summarizes how six regulated cell death modalities—apoptosis, necroptosis, pyroptosis, ferroptosis, autophagic cell...

Harnessing autophagy-dependent ferroptosis: Mechanisms and therapeutic opportunities in human diseases.

Ferroptosis represents an iron-dependent form of cell death driven by lipid peroxidation. Autophagy is an evolutionarily conserved lysosomal degradation pathway, and its dysregulation may trigger or facilitate cell death. Autophagy-dependent ferroptosis (ADF) denotes a specific subtype of ferroptosis executed via selec...

Lead triggers hepatocyte ferroptosis through coordinated mitochondrial injury and ER stress-mediated autophagic degradation of GPX4.

Lead (Pb) is one of the major heavy metal pollutants that induces multi-organ toxicity. Liver is the primary target of Pb, the exposure of which induces hepatotoxicity by triggering hepatocyte cell death. Ferroptosis, a novel iron-dependent form of regulated cell death, has recently been implicated in a variety of heav...

Targeting ferroptosis and oxidative stress crosstalk: a new frontier in stroke neuroprotection