YAP/TEAD complex restricts H3K27ac deposition to suppress testosterone synthesis in adult Leydig cells

Ze-Yu Lin Shanshan Luo Mei Zheng Zi-Hang Lin Lvjing Luo Dini Zhang Xiuli Lian Xuanyi Wang Shie Wang Jian-Dong Sun

Aug 2026 · Histochemistry and Cell Biology · Vol 164 · 0 citations · 43 references

Medicine

TL;DR

It is demonstrated that YAP/TEAD orchestrates postnatal Leydig cell maturation by epigenetically repressing the steroidogenic program, revealing a novel role for the Hippo pathway in male reproductive development and providing insights into the pathogenesis of iNOA.

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