It is shown that OSC number and proliferative capacity decline significantly from pre-laying to late-laying stages, accompanied by increased follicular atresia, and epigenetic repression of the Hippo–YAP axis suppresses OSC proliferation through epigenetic repression of the Hippo–YAP axis.
Precise three-dimensional (3D) genome organization is crucial for regulating gene expression during development, yet its role in age-related transcriptional changes and physiological decline remains elusive. Here, we show that aging reshapes chromatin architecture and gene regulation in murine naive CD4+ T cells, a qui...
Bao Wang, Lu-Zhang Ji, Q. Bian· Science Advances· 0 citations
Rapid hair follicle cycling requires precise fate commitment and differentiation of hair follicle stem cells. While the essential role of transcription factors in establishing cell identity is well recognized, how cells control its protein synthesis to achieve tissue specificity remains unknown. RNA modifications const...
Ch chromatin polyvalency model is established as a multi-layered, hierarchical repression mechanism that governs temporal control of gene expression during embryogenesis and disrupts temporal control of polyvalent gene activation.
Findings not only advance understanding of cell proliferation and cycle regulation but also identify PAFAH1B1 as a candidate gene for further investigation in follicular development.
Yingting He, Yinqi Zhou, Rui-Qi Wang et al.· Frontiers in Cell and Develo...· 0 citations
MBD3 knockdown during bovine iPSC reprogramming significantly enhances the differentiation efficiency of primordial germ cell-like cells (PGCLCs) under a 2D monolayer culture system, providing a mechanistic basis for optimizing bovine iPSC-derived PGCLC protocols through targeted epigenetic modulation.
Wen Yuan, Jing Wang, Wei-Qi Li et al.· Cells· 0 citations
Abstract DNA mismatch repair (MMR) maintains genomic stability, and defects in MMR genes such as MLH1 and MSH2 predispose to cancer. Unlike other MMR components, MLH1 has unexplained roles in development, as Mlh1-deficient male mice exhibit severe testicular hypoplasia and sterility. Here, we uncover that MLH1 regulate...
