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Universal pipeline for high-resolution GPCR structure determination

Asato Kojima Kouki Kawakami Naoya Kobayashi Kazuhiro Kobayashi Toshiki E. Matsui Kohei Uemoto Yu-Zhong Gu Tomohiro J. Narita Mai Kugawa Masahiro Fukuda H. E. Kato
Aug 2026 · Nature Structural & Molecular Biology · Vol 33, pp. 1393 - 1405 · 0 citations · 63 references
Medicine

TL;DR

A universal pipeline that integrates an in silico fusion construct screening program, NOAH, with a de novo designed fusion protein to reduce construct optimization effort and enable rapid high-resolution G-protein-coupled receptor structure determination for drug discovery is introduced.

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