Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse models

Mei Li Díaz Giovanni Tamburini Diego Arriagada Natalia Poblete Álvaro O. Ardiles David Neira Denisse Sepúlveda G. Martínez Romina Gozalvo J. Arcos Claudia Sepúlveda-Quiñenao Els Henckaerts Sérgio T. Ferreira A. Palacios C. Hetz

Aug 2026 · bioRxiv · 0 citations · 56 references

Biology

TL;DR

Treatment of 5xFAD mice with Proteostaser-1 improved spatial learning and synaptic plasticity, and reduced the deposition of amyloid plaques in the brain, which support the therapeutic potential of the UPR as a strategy to ameliorate AD features and sustain synaptic function.

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