Photo-crosslinked gelatin methacryloyl/methacrylated chitosan Janus membrane with covalently integrated bilayers for enhanced guided bone regeneration.
Sep 2026· International Journal of Biological Macromolecules· Vol 383, pp.
154429
· 0 citations
Medicine
TL;DR
This study demonstrates that this dual functional membrane successfully integrates barrier capacity with osteogenic promotion, offering a promising strategy for advanced maxillofacial bone regeneration.
Guided bone regeneration (GBR) is a widely used clinical strategy to separate fast-proliferating epithelium from osteogenic tissue, thereby facilitating alveolar bone defect repair. In this study, a bilayered membrane was engineered by depositing coaxial electrospun Bone Morphogenetic Protein 2 (BMP2)/gelatin core-γ-po...
Yi-Tao Chang, Chuan-Ching Lai, Ying-Tong Chen et al.· International Journal of Bio...· 0 citations
In vitro cellular assays revealed that the CMCSMA/HAMA/Cur composite scaffold demonstrated excellent biocompatibility, with a hemolysis rate below 5%, and facilitated the sustained release of Cur, underscoring its potential for localized drug delivery.
Ya-Xuan Guo, Zhi-Jun Xue, Hui Li et al.· BMC Oral Health· 0 citations
Barrier membranes are used in guided bone regeneration (GBR) to prevent the migration of fibroblastic cells into the alveolar bone defects and to ensure the regeneration of bone tissue. The regeneration capabilities of alveolar bone tissue and connective tissue are different, so the niche required by the tissues must a...
Ceren Keçeciler-Emir, N. Diker, Y. Sahin et al.· Journal of Biomedical Materi...· 0 citations
In vivo evaluation using a critical-sized rat calvarial defect model revealed that the bilayered membrane significantly enhanced new bone formation compared to commercial HAO membranes, as confirmed by micro-CT and histological analysis.
The findings indicate that the Alg/PANI/NPs hydrogel is a promising multifunctional biomaterial that supports regenerative responses through immunomodulatory, antioxidative, and cytocompatible effects.
Bo-Wen Lei, Hua Zhang· Cell and Tissue Banking· 0 citations
In vitro and in vivo results demonstrated that this system synergistically optimizes the immune and osteogenic microenvironments, thereby promoting bone-related regenerative processes and achieving superior bone repair performance compared with the control groups.
Shi-Ze Lei, Di Sun, Yi-Fan Zhang et al.· Bioactive Materials· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.