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Hypoxia‐Induced Lactylation of NSUN3 Promotes m5C Methylation of SETD2 to Regulate Peripheral Nerve Injury Repair

Aug 2026 · Journal of the peripheral nervous system · Vol 31 · 0 citations · 33 references
Medicine

TL;DR

This study explored whether intermittent hypoxia modulates injured dorsal root ganglion (DRG) neuron regeneration via lactate‐mediated mechanisms via lactate‐mediated mechanisms.

Abstract

Peripheral nerve injury (PNI) repair remains challenging, with metabolic regulation and neuronal senescence playing critical roles. This study explored whether intermittent hypoxia modulates injured dorsal root ganglion (DRG) neuron regeneration via lactate‐mediated mechanisms.

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