Integrative single-cell and machine-learning analysis identifies LGALS1 as a macrophage-associated diagnostic and prognostic biomarker in hepatocellular carcinoma

Abstract

Highlights • Single-cell and machine learning defined macrophage-driven LIHC subtypes.• LGALS1 was identified as the top SHAP-ranked therapeutic evasion driver.• LGALS1 was enriched in macrophage and fibroblast lineages in LIHC.• LGALS1 silencing impaired HCC growth, migration, invasion, and clonogenicity.