Oct 2026· Zenodo (CERN European Organization for Nuclear Research)
Abstract
NEUROCODEX presents a revolutionary paradigm shift in neuroscience: the brain is not a computer, but rather the original algorithmic architect from which all artificial intelligence is merely a primitive derivation. This treatise demonstrates how biological systems achieve extraordinary energy efficiency (20 watts versus 21 million watts for supercomputers), single-shot learning, and cross-domain generalization through mechanisms fundamentally distinct from von Neumann architectures. We formalize the biological attention mechanism as precision-weighted prediction error minimization, reframe synaptic learning through biologically plausible Equilibrium Propagation, and advance a mathematically grounded theory of consciousness as optimal Kolmogorov complexity minimization—where subjective experience represents the brain's compression of 11 million bits per second into merely 50 bits of conscious awareness. Neurodegenerative diseases are reclassified as specific algorithmic decoherence failures: Alzheimer's as attention collapse, Parkinson's as motor prediction failure, schizophrenia as prediction error dysregulation, and depression as reward algorithm collapse. The framework yields falsifiable predictions regarding room-temperature quantum coherence in neural microtubules and non-Arrhenius protein folding kinetics. A five-year empirical validation roadmap bridges computational neuroscience, algorithmic information theory, and quantum biology, providing a definitive pathway from crude artificial neural networks to Synthetic Biological Intelligence. The work establishes ethical quantification of synthetic sentience through the El-Rakhawi Resonance threshold, offering unprecedented applications in algorithmic medicine, bio-inspired computing, and the decoding of life's most profound computational mystery.
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It is demonstrated that linker-free PROTACs can outperform traditional designs, marking a paradigm shift in PROTAC development for targeted protein degradation.
Pinal, a 16-billion-parameter foundation model that produces protein candidates from natural-language functional descriptions, supports natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or seque...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.