TL;DR
A strong negative relationship between pH and mass loss indicates that pH is a major mechanistic marker of deterioration, and highlights the importance of scaffold design and nanoparticle incorporation in controlling scaffold biodegradation.
This study provides a practical framework for creating intrafilamentary porosity into 3D-printed PCL scaffolds with improved surface-mediated biological performance.
Overall, PTB4 achieved the best balance among printability, mechanical compatibility, cytocompatibility, angiogenesis-related activity, and osteogenic performance, supporting low-dose BT modification as a promising strategy for safe, printable scaffolds for critical-size craniofacial and oral bone defect repair.
Background/Objectives: Shape-memory biodegradable scaffolds (4D scaffolds) represent promising platforms for minimally invasive tissue engineering and localized drug delivery. This study investigated how two different fabrication techniques, electrospinning (ES) and extrusion-based direct ink writing (DIW), influence t...
The findings support scaffold feasibility and localized delivery, not proven HO prevention, and further disease-model efficacy, biological activity, dose optimization, degradation, and safety studies are required before clinical translation.
This review highlights recent progress in 3D‑printed Alg-based scaffolds for BTE, emphasizing how advanced fabrication techniques and BGs incorporation contribute to improved biological performance and structural reinforcement.
Polylactic acid (PLA) is a biodegradable polymer widely employed in biomedical applications. This polymer can also be applied in additive manufacturing to obtain complex morphologies, even when changes in some of its properties are considered, such as the presence of photoinitiators, additives, and other polymers com...
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