Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis

Julie Tram Célima Mourouvin Laetitia Marty Anika Marie-Delcasse Arnaud Lecante Raymond Césaire P. Hélias Stanie Gaëte V. Baccini Benoît Barbeau Norbert Donhause Andrea K. Thoma-Kress J. Mesnard J. Péloponèse

Jul 2026 · bioRxiv · 0 citations · 63 references

Biology

TL;DR

It is established that HBZ inhibits hnRNPA1 transcription, therefore allowing HTLV-1 to hijack host RNA splicing and to generate an oncogenic isoform that drives transformation and chemoresistance and position HBZ splicing and its regulators as therapeutic targets in ATL.

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