AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
It is found that molecules produced by M2 macrophages, including TGF-β, may promote type 2 immune responses, which may contribute to the pathogenesis of IgG4-RD by activating type 2 immune responses.
PURPOSE OF REVIEW Recent advances in single-cell, spatial, and multiomic technologies have provided new insights into the immunopathogenesis and clinical heterogeneity of IgG4-related disease (IgG4-RD). At the same time, several mechanism-based therapies have entered clinical development. RECENT FINDINGS Recent studi...
Current data support MRGPRX2 as an investigational endotype-defining pathway rather than a universal driver of allergic or immune-mediated disease, and integrates these findings with receptor pharmacology and early clinical development.
BK virus-associated nephropathy (BKVN) is an important cause of kidney allograft failure and involves complex immune responses. This study aimed to characterize gene expression changes and immune microenvironment features in BKVN tissues using transcriptomic analysis. Using the public dataset GSE47199, we performed d...
Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is driven by an overactive immune signaling pathway called type I interferon. Current treatment relies on broadly immunosuppressive agents that lack mechanistic specificity, often fail to achieve durable disease control, and can result in...
This cohort illustrates the broad clinical spectrum of STAT1 GOF disease, including infectious, inflammatory, autoimmune, and hematological manifestations, and BCG disease and tuberculosis were observed in a subset of patients, highlighting the complexity of clinical presentation and the importance of comprehensive eva...
Pneumonia in children is frequently accompanied by excessive inflammatory responses and immune dysregulation, which may lead to severe clinical outcomes. Catechin has shown anti-inflammatory activity in multiple disease settings, but its role and molecular mechanisms in pneumonia remain unclear. Public bulk RNA-sequenc...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.