How the regulatory networking of chaperones by cochaperones, particularly J domain proteins (JDPs; also called Hsp40 or DNAJ proteins), contributes to biocondensate formation and protein disaggregation to maintain proteostasis is discussed.
J1C-PAL is established as a cell-permeable chemoproteomic tool for mapping protein targets and a surprising link between a co-chaperone mimetic and bacterial metabolism is uncovered.
Brock Nelson, Tania J. Lupoli· ChemBioChem· 0 citations
The results reveal distinct ATP- and ADP-state dimer conformations that coexist in equilibrium, and demonstrate that the Hsc70 dimer population is structurally heterogeneous and depends on nucleotide state and cochaperone interactions.
A. Melikov, Vsevolod Viliuga, Daniel Kavan et al.· Journal of Proteome Research· 0 citations
A novel approach is presented that combines pulse metabolic labelling with SILAC and BioID mass spectrometry to temporally resolve protein-protein interactions of a co-chaperone to gain novel insights on how co-chaperone-client interactions may occur over the lifespan of a protein to preserve proteostasis.
Findings indicate that HSPBs, particularly HSPB1 may contribute to mitochondrial stress adaptation prior to Cytochrome c release, which may underlie the modulation of stress-related and degenerative disease progression and contribute to the chemoresistance associated with cancer, which have been attributed to HSPBs.
Ayesha Kiran Mendes, Stijn L. M. In 't Groen, V. de Winter et al.· Cell Death Discovery· 0 citations
Overexpression of Rpt3 enhanced proteasome assembly and activity, reducing intracellular ubiquitin levels in hac1Δ, and upregulates Hac1 protein abundance, thereby ensuring proteostasis maintenance.
Ziting Zhu, Xiaolong Feng, B. Song et al.· The FEBS Journal· 0 citations
An evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress is revealed, revealing an evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress.
Roni Suhler, Lars J. W. van Beurden, Merav D. Shmueli et al.· Proceedings of the National...· 1 citation
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