Aug 2026· microPublication Biology· Vol 2026· 0 citations· 17 references
Medicine
TL;DR
Comparative analyses reveal substantial diversity in tissue expression, intrinsic disorder, and liquid-liquid phase separation (LLPS) propensity, highlighting extensive functional specialization within the C. elegans sHSP family.
Abstract
Small heat shock proteins (sHSPs) are ATP-independent molecular chaperones with diverse cellular functions. Here, we systematically reassessed two subfamilies of sHSPs in C. elegans by integrating evolutionary, genomic, and biophysical analyses. We report analysis of 18 α-crystallin domain-containing sHSPs, including two previously uncharacterized HSP-16-like proteins (designated hsp-16.31 & hsp-16.32 ). This analysis also supports the inclusion of two other proteins, ZK1128.7 and Y55F3BR.6 , as additional members of the C. elegans sHSP family. Comparative analyses reveal substantial diversity in tissue expression, intrinsic disorder, and liquid-liquid phase separation (LLPS) propensity, highlighting extensive functional specialization within the family.
A genome-wide analysis of the HSP gene family is performed to provide a genomic framework for HSP genes in L. vannamei and identify candidate genes and variants associated with thermal stress responses.
Aminah A. Barqawi· Comparative Biochemistry and...· 0 citations
A genome-wide identification and comparative analysis of the CSP gene family in yak is performed primarily using bioinformatics approaches based on publicly available genomic and transcriptomic datasets, along with a preliminary validation of their differential expression under cold and hypoxic stress.
These findings reconstruct the evolutionary emergence of the DGF-1 architecture from pre-existing structural modules and provide a framework for one of the largest and most enigmatic gene families in trypanosomatids.
Mathias J. Mangino, Juan Manuel Trinidad-Barnech, A. Parodi-Talice et al.· bioRxiv· 0 citations
Current knowledge of the THAP proteins structure, localization, transcriptional roles, and disease associations are summarized and new structural analyses that shed light on conserved and divergent features across the THAP family are presented.
B. Rampal, Alexandre Brisson, Louise Ben Hamou Kuijpers et al.· Cellular and Molecular Life...· 0 citations
An evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress is revealed, revealing an evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress.
Roni Suhler, Lars J. W. van Beurden, Merav D. Shmueli et al.· Proceedings of the National...· 1 citation
The results reveal distinct ATP- and ADP-state dimer conformations that coexist in equilibrium, and demonstrate that the Hsc70 dimer population is structurally heterogeneous and depends on nucleotide state and cochaperone interactions.
A. Melikov, Vsevolod Viliuga, Daniel Kavan et al.· Journal of Proteome Research· 0 citations
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