The abstract contains limited description of the BAG due to size limitation. UFM1 (ubiquitin fold modifier 1) is one of the most recent UBLs to be discovered. Protein modification by UFM1 (ufmylation) is essential for the development of different tissues. An increasing body of evidence implicates UFM1 in a wide spectrum of human diseases. However, in spite of its great importance, a gap remains in the basic understanding of the conjugating machinery of UFM1. To that end the Wiener lab studies and continue the study on proteins modification by UFM1. The Akabayev lab will study the time-dependent DNA topological changes induced by gyrase (bacterial Topoisomerase type II) using SAXS. In preliminary experiments topological transitions of DNA formed by gyrase were identified. In another project, they plan to explore the interaction between a small molecule containing phenyl thiazole and an RNA hairpin located within the ribosomal peptidyl transferase center.
The comparison of adopter and non-adopter sample reveals three potential adoption inhibitor, security, data privacy, and portability, which underlines the importance of the technical and security perspectives for research investigating the adoption of technology.
Nattakarn Phaphoom, Xiaofeng Wang, S. Samuel et al.· Journal of Systems and Softw...· 111 citations· ⚡8
This study investigates how Lean internal startup facilitates software product innovation in large companies and identifies its enablers and inhibitors, and shows the potential of the method-in-action framework to investigate the Lean startup approach in non-startup context.
Henry Edison, Nina M. Smørsgård, Xiaofeng Wang et al.· Journal of Systems and Softw...· 78 citations· ⚡6
This paper highlights the challenges to conduct proper affect-related studies with psychology, provides a comprehensive literature review in affect theory, and proposes guidelines for conducting psychoempirical software engineering.
D. Graziotin, Xiaofeng Wang, P. Abrahamsson· SSE@SIGSOFT FSE· 56 citations· ⚡4
This study conducts a multiple case study on twenty European software startups and proposes a prototype-centric learning model in early stage software startups, and identifies factors that occur as barriers but also facilitators for prototyping in earlystage software startups.
Anh Nguyen-Duc, Xiaofeng Wang, P. Abrahamsson· International Conference on...· 44 citations· ⚡5
It is demonstrated that linker-free PROTACs can outperform traditional designs, marking a paradigm shift in PROTAC development for targeted protein degradation.
Pinal, a 16-billion-parameter foundation model that produces protein candidates from natural-language functional descriptions, supports natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or seque...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
