The Vascular Genome as a Therapeutic Target: A Systematic Review of CRISPR-based Gene Editing In Vascular Disease

TL;DR

CRISPR/Cas9-mediated genome editing of these targets modulates critical biological pathways, resulting in enhanced nitric oxide production, improved endothelial function and angiogenesis, reduced oxidative stress and inflammatory signaling, decreased lipid accumulation and plaque formation, restoration of vascular smooth muscle cell contractility, and overall improvement in vascular health.