Sep 2026· Nuclear Medicine and Biology· Vol 162-163, pp. 109682 - 109682· 0 citations· 112 references
Medicine
TL;DR
Recent investigations with [11C]HCN include its production, radiochemistry, and use in developing new PET radiopharmaceuticals including its production, radiochemistry, and use in developing new PET radiopharmaceuticals.
Abstract
The identification of efficient radiochemical methods has been a long-standing challenge in the development and production of positron emission tomography (PET) tracers. Carbon-11, being a short-lived (t1/2 = 20.4 min) isotope, offers a unique set of challenges for regulatory-compliant radiochemistry with exceptional time constraints. Simultaneously, the diversity of radiochemical scaffolds available from carbon-11 maintains its importance in clinical PET radiosynthesis. [11C]Hydrogen cyanide ([11C]HCN) represents a unique example of a versatile 11C-synthon that can deliver broad chemical diversity for the synthesis of 11C-labeled PET radiopharmaceuticals. This review article describes recent investigations with [11C]HCN including its production, radiochemistry, and use in developing new PET radiopharmaceuticals.
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