TL;DR
Key genetic engineering approaches, including CRISPR-based genome editing, transcriptional and translational regulation, and modular DNA assembly, and modular DNA assembly are discussed together with strategies for metabolic pathway design, enzyme engineering, flux balancing, and dynamic regulation.
Yeasts serve as premier eukaryotic hosts for microbial cell factories, enabling the production of recombinant proteins, biofuels, and high-value natural products. Precise transcriptional control is paramount for balancing complex metabolic pathways and maximizing target product yields. Promoters, as the key regulatory...
An integrated perspective on the evolution of biological parts across DNA-, RNA-, and protein-level regulation is provided, connecting these advances with assembly frameworks, biofoundries, and machine learning to trace the trajectory from part-centric engineering toward predictive, system-level design in yeast synthet...
Lactic acid bacteria (LAB) are generally recognized as safe, which makes them ideal hosts for producing food-related chemicals. Traditional metabolic engineering has mostly focused on editing one or a few genes, which often fail to meet the demands of industrial production. High-throughput metabolic engineering based...
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