New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors

Exploring longitudinal relationships among Alzheimer's disease biomarkers

While most studies of Alzheimer's disease (AD) examine cross‐sectional relationships among biomarkers, longitudinal relationships are also highly relevant.

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery

We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs).

Epigenetic aging in Alzheimer's disease: Relation to proteome

Alzheimer's disease (AD) arises from heterogeneous biological processes, and long‐term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.

Prospective study on physical activity and Alzheimer's disease–related biomarkers

Evidence regarding the association between physical activity (PA) and Alzheimer's disease (AD)–related biomarkers is scarce and inconsistent.

The role of polygenic risk in Alzheimer's disease prediction for African Americans

African Americans (AAs) face a higher risk of Alzheimer's disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored.

Elucidating the mechanisms underlying Alzheimer's disease-Elucidating the mechanisms underlying Alzheimer's disease-associated genetic polymorphisms associated genetic polymorphisms