Aug 2026· European Archives of Psychiatry and Clinical Neuroscience· Vol 276, pp. 3765 - 3775· 0 citations· 27 references
Medicine
TL;DR
The AD-specific transcriptomic risk scores (TRSs) developed in this study shows promising clinical utility in AD diagnosis, differential diagnosis, and risk prediction, providing valuable translational medical evidence for early screening and precision prevention of Alzheimer's disease.
Early and accurate diagnosis is critical for intervening in the progression of Alzheimer’s disease (AD). However, traditional clinical diagnostic techniques, such as invasive cerebrospinal fluid punctures and expensive neuroimaging, struggle to meet the demands of large-scale early screening.
This study prop...
Xiao-Lan Zhang, Xiao-Tong Tang, Qian Bo et al.· Frontiers in Genetics· 0 citations
Background/Objectives: Alzheimer’s disease (AD) shows marked transcriptomic heterogeneity across brain regions, limiting reproducibility. We aimed to identify robust cross-region gene signatures using meta-analysis. Methods: Differential expression (limma-voom) was performed on five bulk RNA-seq datasets (n = 230; 154...
Kashvi C. Shah, Ethan Littlestone, M. R. Ahmmad et al.· Biomedicines· 0 citations
Rare and common variants in AD- and neurodegenerative biomarker-associated genes with increased frequency in India compared to other populations may impact blood levels of neurodegenerative biomarkers in South Asians.
Hasan Abu-Amara, Wei Zhao, Zheng Li et al.· Frontiers in Aging Neuroscie...· 0 citations
The GO and pathway enrichment analysis results revealed that the up regulated genes were mainly enriched in response to stimulus, cytoplasm, small molecule binding and signal transduction, whereas down regulated genes were mainly enriched in multicellular organism development, cell junction, ion binding and cardiac con...
B. Vastrad, Shivaling Pattanashetti, C. Vastrad· Ageing International· 0 citations
Background Prostate cancer (PCa) and Alzheimer’s disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options. Identifying shared molecular drivers may reveal new treatment targets. Objective To identify common transcriptomic signatures between PCa and AD and validat...
Meng-Xue Wang, Yan-Rong Qian, En-Yao Huang et al.· Frontiers in Immunology· 0 citations
BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory impairment, and functional deterioration. Its complex pathogenesis involves amyloid plaques, tau tangles, neuroinflammation, synaptic dysfunction, and interacting genetic, environmental, and lifestyle factors....
Jerome J. Choi, C. Engelman, Tianyuan Lu· Journal of Alzheimer's Disea...· 0 citations
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