The nucleus is a highly organized and dynamic organelle, with hierarchical layers ranging from nucleosome positioning to chromatin domains and higher-order 3D genome topology, and this organization enables precise and context-dependent transcriptional control.
A comprehensive synthesis of the mechanisms and functional roles of classical chromatin remodelers within both physiological and neoplastic contexts is provided and a hierarchical framework that distinguishes between 'first-level' and 'higher-order' chromatin remodeling is proposed.
A unified view is provided of how genome structure is established, how it relates to function, and how its disruption contributes to tumorigenesis, suggesting that alterations in genome structure can, in some contexts, actively reshape oncogenic programs.
Rebecca G. Smith, Hannah M. Wilson, Kathleen L. Schiela et al.· Genes & Development· 0 citations
The role of nuclear architecture in tumorigenesis, the contribution of lamins to chromatin organization, and the emerging epigenetic control of lamins in cancer progression and metastasis are discussed.
The regulation of nuclear LaminB structure and function is emerging as a stress-integration gatekeeper controlling neuronal response to macro/micro-environmental biophysical and biochemical cues, which maintains neuronal health, and whose impairment drives neuronal aging and non-apoptotic cell death in neurodegenerativ...
F. Napoletano· Frontiers in Cell Death· 0 citations
This work combines HiC and ATAC-sequencing to map 3D chromatin architecture and accessibility in LECs and blood endothelial cells (BECs), and identifies cell type-specific topologically associating domains (TADs), and discovered TAD boundaries changes and differentially segregating enhancers in lymphatic-associated loc...
Virginia Panara, Hannah Arnold, Marleen Gloger et al.· EMBO Reports· 0 citations
A unified mechanistic framework by which the level of YAP/TAZ activity determines enhancer landscapes that favor either differentiated or progenitor-like cellular states is proposed, providing a potential basis for applications to regenerative medicine and therapeutic interventions.
Ju-Gyeong Kang, Taejun Seol, Younghoon Kim et al.· Cold Spring Harbor Perspecti...· 0 citations
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