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The mediating role of inflammation and nutrition metabolism in the methylmalonic acid-stroke association

Jan 2026 · Clinics · Vol 81, pp. 101055 · 0 citations · 39 references
Medicine

TL;DR

Elevated MMA levels are associated with increased stroke risk in US adults and combined detection of NLR, TG, and FPG may help identify populations at elevated stroke risk in this cross-sectional exploratory analysis.

Abstract

Highlights • Elevated MMA levels are associated with increased stroke risk in US adults.• Restricted cubic spline analysis identified a nonlinear relationship between MMA and stroke, with a cutoff at ln (MMA = 5).• The MMA-stroke correlation is stronger in younger adults than in older adults (P for interaction = 0.013).• Combined detection of NLR, TG, and FPG may help identify populations at elevated stroke risk in this cross-sectional exploratory analysis.

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