THINKERS-X: multisequence MRI radiomics in a mixture-of-experts model for outcome prediction and exploratory dose-scenario evaluation in lung cancer brain metastases treated with radiosurgery
Oct 2026· Clinical and Experimental Metastasis· Vol 43· 0 citations· 29 references
Medicine
TL;DR
THINKERS-X improved lesion-specific longitudinal prediction, temporal accuracy, and probabilistic calibration beyond THINKERS-Lung while materially altering exploratory dose-scenario evaluation in a subset of metastases.
THINKERS-Breast provides an internally validated framework for tumor-specific local failure prediction and dose-policy evaluation after Gamma Knife radiosurgery for breast cancer brain metastases.
J. Reyes, A. Niranjan, Constantinos G. Hadjipanayis· Frontiers in Oncology· 0 citations
MRI radiomics showed promising discrimination for local recurrence but limited discrimination for metastasis, and should be interpreted with caution given the small number of events in the test set and warrant external validation in larger cohorts.
Yusuf Baytar, Fırat Atak, G. Yazici et al.· European Journal of Ophthalm...· 0 citations
Serial magnetic resonance imaging (MRI) reveals heterogeneous lesion responses after stereotactic radiosurgery beyond binary local-control status. We characterized latest-observed volumetric response categories after Gamma Knife radiosurgery (GKRS) for breast cancer brain metastases and examined their concordance...
Si-Jun Diao, Tao Huang, Zhong-Yu Li et al.· Frontiers in Medicine· 0 citations
INTRODUCTION
Deep learning-based dose prediction has emerged as a promising approach for supporting automated radiotherapy planning workflows by estimating three-dimensional dose distributions from patient imaging. Although planning CT remains the standard imaging modality, multisequence MRI provides anatomical and tis...
S. Singh, S. Sen, A. Singh et al.· Radiography· 0 citations
T1 postcontrast MRI radiomics showed limited standalone discrimination for overall survival in patients with brain metastases, which support cautious use of radiomics as an exploratory imaging biomarker and emphasize the need for integrated prognostic models that include clinical, treatment, molecular, and systemic dis...
H. Salim, Evan Calabrese, Ahmed Naeem et al.· AJNR. American journal of ne...· 0 citations
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