Jul 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 59 references
Medicine
TL;DR
Findings highlight the compound 5d as a promising scaffold against S. aureus infections and successfully establish the sulfonylated-indole hydrazones as capable pharmacophores for next-generational antibacterial drug discovery efforts to mitigate the global AMR burden.
In vivo experiments confirmed that Ru-6 effectively eradicates MRSA without significant toxicity to host tissues, andRu-6 exhibits considerable potential as a novel antimicrobial agent for clinical application.
Wen-Ping Wang, Wei Deng, Jin-Tao Wang et al.· Bioorganic chemistry (Print)· 0 citations
This review critically evaluates recent advances in nitrogen- and oxygen-containing heterocyclic compounds, including imidazolidine, quinoline, triazole, quinoline–triazole hybrids, and other hybrid pharmacophores, as promising antimicrobial, antibiofilm, and antivirulence agents and emphasizes the integration of medic...
M. Sankaran, Kiruthiga Kaliyamoorthy, Karthigai Meena Pitchumani· Interactions· 0 citations
Findings identify 5D as a promising honokiol-derived anti-MRSA lead compound that acts mainly by disrupting membrane integrity and phospholipid homeostasis.
Mu-Chen Zhang, Yan Wang, Jing Pan et al.· Bioorganic chemistry (Print)· 0 citations
Evaluating the antibacterial and antibiofilm activity of mocravimod hydrochloride (KRP-203), an FDA-approved S1P receptor modulator, against clinical S. aureus isolates revealed its potential as a repurposed antibacterial agent, but further studies are required to fully elucidate its molecular targets, optimize antibac...
Mechanistic study showed that 24a effectively inhibits biofilm formation and exerts its antibacterial effect by disrupting the bacterial cell membrane, paving the way for new strategies to combat antimicrobial resistance.
Qiong Wu, Bing-Yuan Yan, Chen Qu et al.· Chinese Journal of Natural M...· 0 citations
Carvacrol markedly enhanced the bactericidal activities of Gentamicin (Gen) against MRSA, indicating that Car may serve as a natural antibacterial adjuvant for combination therapy against drug-resistant infections.
