Plasma proteomics identi fi es four candidate biomarkers associated with macrovascular complications in type 2 diabetes: evidence from a clinical cohort and an animal model
Four candidate proteins were prioritized: adenylosuccinate lyase (ADSL), galectin-3 (LGALS3), mannosyl ( a -1,3)-glycoprotein b -1,2-N-acetylglucosaminyltransferase (MGAT1), and V-set and immunoglobulin domain-containing protein 4 (VSIG4) and the four-protein panel showed good discrimination.
To identify and validate plasma protein biomarkers for T2DM macrovascular complications through proteomic screening, clinical validation, and animal models.
Plasma proteomics (4D-DIA, n = 6/group) was used to screen candidate proteins via differential expression, WGCNA, and PPI analyses. Candidates were vali...
Nuo Chen, Jing-Xuan Wang, Xiao-Jing Yuan et al.· Frontiers in Endocrinology· 0 citations
Persistent downregulation of pancreatic digestive enzymes supports exocrine pancreatic involvement as a durable feature of T1D, remaining evident in adolescents more than a decade after diagnosis despite good metabolic control and widespread use of advanced diabetes technologies.
M. Taube, D. Swolin-Eide, A. P. Lyckå et al.· Hormone Research in Paediatr...· 0 citations
A validated lipid-metabolism-based diagnostic signature with potential for early detection, molecular stratification, and mechanistic investigation is revealed.
Qing-Bu Mei, Xin-Yu Liu, Jing Xu et al.· Iranian Journal of Basic Med...· 0 citations
SLC3A2 emerged as a candidate biomarker that may complement existing clinical scoring systems, although its incremental and independent prognostic value requires confirmation in larger external cohorts.
Sheng-Ling Wang, Xi-An Yan, Wei Wang et al.· Scientific Reports· 0 citations
Any relationship between these genes and the neurological manifestations of T2DM remains speculative and hypothesis-generating, and requires prospective validation in cohorts with matched neurocognitive data.
Genetic analyses prioritized angiotensin-converting enzyme as a candidate target, and a conventional observational analysis in a large prospective cohort provided supportive evidence that regular angiotensin-converting enzyme inhibitor use was associated with a higher AD risk.
Pei-Guan Huang, Hai-Bo Tang, Ze-Ying Feng et al.· Journal of the American Hear...· 0 citations
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