Sep 2026· Civil society in Russia and abroad· 0 citations
Abstract
This article is devoted to the legal regulation of the use of genomic editing technology in individual states. In general, it can
be stated that in most legal systems there are restrictions on genomic editing in relation to hereditary genes, however, in rare cases
exceptions are allowed, which must be recognized as justified in view of the reality of threats to human life and health. Using the method
of comparative legal analysis, the author identifies the most optimal experience that can be useful to the domestic system of law-making
on the way to forming legislation in the field of public health protection.
Several legal frameworks governing the use of CRISPR technology in humans are analyzed, with a particular focus on Indian biotechnology regulations, which identifies crucial shortcomings in the existing biomedical policies and carves a pathway for better regulation and widespread acceptance towards this groundbreaking technology.
Manveen Singh, Aditi Morale· LAW & PASS: Internationa...· 0 citations
Explicit appeals for the protection of individual autonomy in the hereditary editing of the human genome are
increasingly being heard in the scientific literature. The author attempts to consider the category of personal autonomy
through the prism of philosophy, ethics and law (including the decisions of the European Court of Human Rights
and the Constitutional Court of the Russian Federation) and to establish the possibility of its implementation when
deciding on the editing of the embryo germline. An analysis of the multivariative nature of personal autonomy has shown that the full realization of autonomy is possible only by the individual himself, and this requires the search
for other adaptive approaches to its implementation in the context of genomic editing technology. As a solution,
it is proposed to consider the possibility of implementing the principle of individual autonomy when deciding
on the editing of the embryo’s germline through compliance with the requirements of respect and protection of human
dignity.
Aleksandr A. Kushnarev· Constitutional and municipal...· 0 citations
Today, due to significant advances in science, particularly in the field of genetic engineering, some individuals have not limited their use of genetics merely to gene correction, disease treatment, and therapy. Instead, they have gone further, utilizing genetic science to make alterations to their embryos based on personal desires and preferences, such as changing eye color, enhancing memory, determining gender, and more. In many cases, genetic manipulation of the embryo does not lead to the desired or expected outcome for the parents, and may even result in adverse effects, causing defects or abnormalities in the embryo. This article, using the library research method and referencing legal sources and scholarly opinions, examines the factors involved in genetic manipulation of embryos and the liability arising from such actions. The summary of the research suggests that genetic specialists, gynecologists, and laboratory staff, when acting based on customary standards, are liable for any damage caused to the embryo and must compensate for the harm. It is noteworthy that due to customary reliance, their responsibility may sometimes be determined as joint liability due to direct involvement, stronger causality, or the participation of all contributing factors.
Fariba Taei, Aliakbar Ezadifard, A. Jahani· Comparative Studies in Juris...· 0 citations
This review systematically elucidates the working principles and technical advantages of the CRISPR-Cas9 system and its derived tools (base editing and prime editing), summarizes recent applications of these technologies in the treatment of hereditary liver diseases, and discusses the prospects and challenges of their clinical translation.
Ran Liu, Shiqi Cong, Yuan Gao et al.· International Journal of Mol...· 0 citations
Future development directions lie in integrating artificial intelligence to optimize editing design, perfecting lifelong safety monitoring systems, constructing ethical consensus across multicultural backgrounds, promoting deep synergy between technological innovation and humanistic care, and ultimately achieving a paradigm shift in genetic disease treatment from symptom management to etiological eradication.
Zhiyi Jiang· Critical Humanistic Social T...· 0 citations
Mexico's General Health Law regulates certain transfers abroad of human tissues used in population genomic studies. We clarify how this framework may apply to oriGen, why the nature of the material transferred is legally decisive, and why publicly verifiable clarification of the applicable permit and registry requirements is essential for regulatory accountability, participant trust, lawful national stewardship, and responsible, equitable international genomic collaboration.
M. T. Hernández-Huerta, Gilberto Castañeda-Hernández, H. A. Cabrera-Fuentes· Trends in Biotechnology· 0 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
