Review

Beyond nuclear export: chromatin-bound XPO1/CRM1 as a transcriptional scaffold.

M. Oka

Aug 2026 · International journal of hematology · 0 citations · 71 references

Medicine

TL;DR

From a reframing XPO1 from a nuclear export receptor to a chromatin-associated interaction hub, this perspective provides a framework for understanding transcriptionally addicted AML subtypes and highlights opportunities to selectively target chromatin-associated XPO1 functions in HOX/MEIS-driven AML.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Open access Jul 2026

Plant LHP1 as a Context‐Dependent Regulator of Polycomb‐Associated Chromatin

This review outlines emerging roles of LHP1 in Polycomb‐mediated repression, chromatin‐state maintenance, transcriptional responsiveness, hormone signaling, stress responses, and TE‐proximal gene regulation and highlights future directions involving genome editing, epigenomic profiling, chromatin conformation analysis,...

Rehman Sarwar, Xiang Fan, Ke Dong et al. · Physiologia Plantarum : An I... · 0 citations

Aug 2026

Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB.

A novel interconnected regulatory cascade triggered by nuclear translocation of GDOWN1 is uncovered: it remodels Pol II phosphorylation landscape and induces global transcriptional repression, which further drives cytoplasmic kinase-phosphatase coordination to activate master cell cycle suppressors and ultimately arres...

Zhanwu Zhu, Jin-Jing Hu, Wen-Yuan Zhu et al. · Cell Death and Differentiati... · 0 citations

Open access Sep 2026

Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling

The results identify an in vivo silencing role of a Nup93 paralog and suggest that Nup93-2 may form a unique NE-associated complex that targets a subset of Polycomb domains containing growth-promoting genes.

M. O’Sullivan, J. Hartmann, M. Mclellan et al. · bioRxiv · 0 citations

Open access Aug 2026

Acidic transcription factors position the genome at nuclear speckles through transcription dependent and independent mechanisms

This work demonstrates establishment of genome-wide NS-association without active transcription and establishes diverse and partially redundant NS-targeting activities, which may facilitate dynamic gene positioning at NS periphery for context-specific transcriptional responses.

Pankaj Chaturvedi, Purnam Ghosh, Liguo Zhang et al. · Molecules and Cells · 0 citations

Aug 2026

LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

This study uncovers a therapeutic vulnerable lncRNA-centric circuitry and provides compelling preclinical evidence for the development and application of a novel RNA targeting-LNP based therapy for treatment of myeloid leukemia.

Zhenggen Jin, Brendan D. Ma, Karen Y. T. Chan et al. · bioRxiv · 0 citations

Open access Aug 2026

J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition

It is found that transcriptional outcome of PKL binding depends not only on the changes in H3.3 occupancy but also on the pre-existing chromatin context at PKL-targeted sites, which outlines a new mechanism for CHD3 chromatin remodeler recruitment and function.

Shu-Ya Wang, Colette L. Picard, Zhong-Shou Wu et al. · bioRxiv · 0 citations