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Meta-analysis Open access

A Genome‐Wide Meta‐Analysis of Functional Dyspepsia in 1,168,899 Individuals Implicates Immune Pathways in Disease Susceptibility

Cristian Díaz-Muñoz B. Broeders Ferdinando Bonfiglio A. Zamfir-Taranu J. Arts P. Bánovčin L. Bujanda V. Drug D. Dumitrascu G. Gourcerol Sébastien Kindt Peter Lipták C. Melchior C. Malagelada E. Savarino Artemis Trikola J. Lehoucq F. Carbone Jan Tack Mauro D'Amato
Oct 2026 · Neurogastroenterology and Motility · Vol 38 · 0 citations · 60 references
Medicine

TL;DR

This work aimed to identify FD genetic risk factors and implicated biological pathways, and implicated biological pathways inFunctional dyspepsia.

Abstract

Functional dyspepsia (FD) affects over 7% of the global population, impairing quality of life and driving significant healthcare burden. Although genetic contributions to FD pathophysiology have been suspected, large, well‐powered genetic studies remain limited. We aimed to identify FD genetic risk factors and implicated biological pathways.

DOI PubMed Semantic Scholar
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