Aug 2026· Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences· Vol 58 4, pp.
707-715
· 0 citations
Medicine
TL;DR
This study successfully identified CX3CL1 as a potential negative regulator of TLS formation in bladder cancer through CRISPR-Cas9 library screening combined with in vivo validation, and provides new clues and research directions for understanding the molecular mechanisms of TLS formation.
In conclusion, VENTX is a key regulator of seminoma stemness, presenting a promising target for therapy to address recurrence and resistance in seminoma.
The generation of a WSL-Cas9 monoclonal cell line with high CRISPR/Cas9 editing efficiency, stable proliferation, and permissiveness for robust ASFV replication is reported, providing a reliable platform for future genome-wide functional screening to systematically identify host factors governing ASFV entry.
Meng Yao, Tianlong Li, Bin Sun et al.· Sheng wu gong cheng xue bao...· 0 citations
Tumor infiltration regulatory T cells (Tregs) mediate immune escape by highly expressing multiple inhibitory receptors, which is one of the key factors in resistance to existing immune checkpoint inhibitors. However, systematic screening of Treg-specific immune checkpoints within tumors remains lacking. This study aims...
Gang Liu, Jia Wang, Li-Qiang An· Injury and Rehabilitation Ca...· 0 citations
It is hypothesized that genome-wide CRISPRa screening will uncover subtype-specific genetic dependencies and drug resistance mechanisms, offering novel therapeutic insights in leukemia subtype biology, guiding future personalized treatment strategies.
Jeffrey Sullivan, Xiaozen Wen, Gabriela Flores-Vargas et al.· Journal of Immunology· 0 citations
A candidate-based CRISPR activation (CRISPRa) functional screen is developed to identify regulators of conventional dendritic cell (cDC)-fate specification and concludes that the transcription factors Zfp366/Znf366, Pu.1, Irf8, and Batf3 (ZPIB) are sufficient to convert GBM cells into cDC-like cells.
Xiao Liu, Mao-Rong Zhu, Cheng Zou et al.· Cell Reports Medicine· 0 citations
Immunity protection from macrophages is revealed as an adverse consequence of hormonal therapy in prostate cancer patients using a genome-wide co-culture CRISPR screen and positions tumor-intrinsic AR signaling as a bona fide immunomodulatory pathway.
Anniek Zaalberg, Audrey Lacoste, Emma Minnee et al.· Oncogene· 0 citations
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