Clinical, genetic, and neuropathologic correlates of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC): A systematic review and meta-analysis.
Jul 2026· Journal of Neuropathology and Experimental Neurology· 0 citations
Medicine
TL;DR
A first-of-its-kind meta-analysis outlines a distinct pattern of correlates associated with LATE-NC, emphasizing its strong linkage to AD-related and multimorbid neuropathologic processes, and underscoring the need for refined diagnostic frameworks and future mechanistic studies to differentiate LATE-NC from coexisting neuropathologies.
Clinically, LATE presents with a gradually progressive amnestic dementia syndrome similar to AD which complicates diagnosis, and definitive diagnosis relies on postmortem confirmation, so continued research is critical to develop effective biomarkers and therapies for this prevalent but under-recognized TDP-43 proteino...
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