Gramicidin D as a Multi-Target Antimicrobial Against Staphylococcus aureus: Biofilm Disruption, Virulence Attenuation, Antibiotic Potentiation, and Protein-Peptide Docking Insight.

Discovery of a Novel Benzothiophene Inhibitor of Penicillin-Binding Protein 2 with Potent Gram-Positive Activity

Background/Objectives: The emergence of methicillin-resistant Staphylococcus aureus (MRSA) highlights the need for new antibacterial agents. Here, we report the identification and evaluation of a novel Gram-positive selective antibacterial: NDM-552. Methods: Antibacterial activity was determined by broth microdilution...

Structure-based identification of potential inhibitors of essential Staphylococcus aureus enzymes with in vitro antibacterial screening

This study presents a structure-based screening workflow that identified potential inhibitory hits supported by in vitro antibacterial evaluation that may reduce the likelihood of resistance emergence by simultaneously disrupting multiple essential bacterial pathways.

Antibacterial and Antibiofilm Activity of Aspergillus-Derived Gliotoxin Against Streptococcus pneumoniae and Staphylococcus aureus: Interaction with Conventional Antibiotics

Antimicrobial resistance and the formation of biofilms in Gram-positive pathogens such as Streptococcus pneumoniae and Staphylococcus aureus are making the treatment of infections increasingly difficult. This study systematically evaluates the effect of gliotoxin (GT), an antimicrobial metabolite produced by Aspergillu...

Phage–Antibiotic–Peptide Synergy Overcomes Biofilm-Mediated Multidrug Resistance in Serratia marcescens

Background/Objectives: Serratia marcescens is an opportunistic pathogen that causes severe hospital-acquired infections, notable for its biofilm formation abilities and development of extensive antibiotic resistance. Here, we aim to evaluate the efficacy of bacteriophages, antibiotics, and antimicrobial peptides (BAP),...

Synergistic effects of luteolin and Lactobacillus rhamnosus on methicillin-resistant Staphylococcus aureus biofilm inhibition: in vitro and in silico molecular deployment studies.

Hydrothermal synthesis of silver vanadate nanoparticles, antimicrobial and anti-inflammatory potentials, cytotoxicity and interference on the activity of antimicrobial drugs

It is suggested that SVM is a promising candidate for combination therapy, warranting further investigation with surface-functionalized formulations to improve its selectivity.