Jul 2026· International Journal of Biology and Life Sciences· Vol 15, pp. 17-20· 0 citations· 43 references
TL;DR
This review covers the molecular structure of mRNA vaccines, synthesis and purification technologies including nucleoside modification and LNP delivery systems, applications in infectious disease prevention and oncology treatment, and prospects for future development.
Abstract
mRNA vaccine is a novel category in the medical field. Its core mechanism is to deliver mRNA into cells, and then use the host cell system to produce therapeutic proteins or immunogenic proteins, exerting therapeutic effects on the body or stimulating the body to produce antibodies. In addition to COVID-19, mRNA vaccines’ application in targeted tumor therapy is expanding, with numerous clinical trials underway. This review covers the molecular structure of mRNA vaccines, synthesis and purification technologies including nucleoside modification and LNP delivery systems, applications in infectious disease prevention and oncology treatment, and prospects for future development.
: As one of the disorders with the highest mortality rate, cancers are continuously promoting the exploration of new kinds of therapeutic strategies. Among them, mRNA therapeutic cancer vaccines have become a highly promising research direction because of their high quality and research potential. Moreover, their devel...
Ziyuan Liu· Proceedings of the 1st Inter...· 0 citations
: Veterinary mRNA vaccines represent a significant breakthrough in biomedical research in recent years, demonstrating broad application prospects in animal disease prevention and control. This review summarizes the overall research background, achievements, existing challenges, and future development of this technology...
Junyi Zhang· Proceedings of the 1st Inter...· 0 citations
Vaccines that use messenger RNA (mRNA) have become a promising platform that is transforming cancer immunotherapy. These mRNA vaccines can be generated and manufactured quickly due to their modular design and can also induce CD4⁺ T-cell and CD8⁺ T-cell responses, in contrast to conventional protein or peptide-based vac...
Zahraa A. Alkhafaje, M. H., Aniruddh Dash et al.· Current Research in Translat...· 0 citations
The role of immunotherapy in the care of surgical oncology patients promises to expand as investigators and clinicians evaluate new targets and approaches. Currently active clinical trials evaluate new immune checkpoints, including lymphocyte activation gene 3, T cell immunoreceptor with Ig and ITIM domains, and killer...
S. Schokrpur, M. G. White, C. Roland et al.· Hematology/Oncology Clinics...· 0 citations
Cancer vaccines represent a promising class of immunotherapeutic agents with potential applications in cancer prevention and treatment. By eliciting tumor-specific immune responses, these vaccines may offer durable protection against tumor progression, recurrence, and metastasis while minimizing off-target toxicity ass...
Messenger RNA vaccines have moved rapidly from the infectious-disease area into oncology. They now represent an attractive therapeutic option for gastrointestinal (GI) cancers. Personalised constructs, designed to elicit tumour-specific T-cell immunity, have shown acceptable safety and clear immunogenicity in early-pha...
M. Ghidini, Federica Novazzi, N. Denaro et al.· Cells· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
