It is shown that Satb1 expression in mature B cells is controlled by alternative promoter usage and splicing, with promoters P1 and P3 dynamically switching upon LPS-induced activation, while P2 remains transcriptionally silent.
It is suggested that YY1 preserves B cell identity through coordinated regulation of transcriptional and post-transcriptional programs, with YY1-dependent miRNA networks contributing to the maintenance of B cell-associated gene expression and restriction of alternative lineage programs.
Nasreen Bano, Sarah Naiyer, Sulagna Sanyal et al.· bioRxiv· 0 citations
This review summarizes RBM15 structure, function, and regulation, and highlights its emerging roles in leukemia, including AMKL and myelodysplastic syndromes, while outlining key questions for future studies.
Jether Amos Espinosa, Madeline Y. Mayday, Abigail R. Robb et al.· Trends in Cancer· 0 citations
It is shown that ACTL8 surprisingly localizes to the nucleus of spermatogonia in human testes and breast and lung cancer cells, and Mechanistically, it is found that ACTL8 interacts with KDM5B, an H3K4 demethylase and transcriptional repressor, and this interaction contributes to changes in migration.
Nuria Cortes-Silva, Sanjana Banerjee, Kristen Dominique Amarillo et al.· bioRxiv· 0 citations
It is demonstrated that post-transcriptional regulation of the Profilin 2 (Pfn2) transcript is essential for differentiation of embryonic stem cells into the primary germ layer lineages and revealed the Pfn2 microRNA-IRE regulatory axis as a critical post-transcriptional regulatory node governing the switch from plurip...
Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh et al.· PLoS Genetics· 0 citations
It is shown that in muscle and neural cells that have ceased to replicate their chromatin and permanently exited the cell cycle, HLBs are dismantled and NPAT, FLASH and Lsm11 are detected in the cytoplasm, suggesting that in postmitotic cells, NPAT and U7 snRNP become repurposed for functions unrelated to generating hi...
Xiao-cui Yang, Anthony Desotell, Agata Malinowska et al.· Biology Open· 0 citations
Multi-omics integration across RNA-seq, miRNA, scRNA-seq, and scATAC-seq datasets allowed the construction of YY1-dependent regulatory networks that reveal how YY1 influences B-cell lineage plasticity.
Nasreen Bano, Sarah Naiyer, Sulagna Sanyal et al.· Journal of Immunology· 0 citations
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