Aug 2026· Free Radical Biology & Medicine· Vol 256, pp. 15-30· 0 citations
Medicine
TL;DR
In vitro experiments revealed that IMA induced PANoptosis, characterized by membrane blebbing and swelling, pyknosis, as well as rupture of the nuclear and plasma membranes observed, which suppressed IMA-induced PANoptosis, and improved granulosa cell viability and oocyte quality.
Celastrol, a quinone methide triterpenoid derived from the root bark of Tripterygium wilfordii Hook. f., has antitumor activity, but its molecular mechanisms in hepatocellular carcinoma (HCC) remain incompletely defined. This study investigated whether celastrol suppresses HCC through LRP6-associated modulation of Wnt/...
Yi-Xuan Wang, Dan-Dan Wang, Jing-Hao Fu et al.· Biochemical Pharmacology· 0 citations
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is a hallmark of prostate cancer (PC) progression. Here, we investigated the anticancer effects of artesunate (ART) and its underlying mechanisms in PC. ART selectively reduced the viability of PC cells with minimal toxicity toward no...
Young Y. Jung, Alamelu Nachiyappan, Na Young Kim et al.· Archives of Biochemistry and...· 0 citations
Background: Drug repurposing represents an accelerated and cost-effective approach to discovering novel oncologic therapeutics. Here, we investigated the anticancer potential and underlying mechanisms of marbofloxacin (MBF), a veterinary fluoroquinolone (FQ), against breast cancer (BC) cells. Methods: The cellular impa...
M. Yavuz, F. R. P. Dewi, Ilknur Keskin et al.· Pharmaceuticals· 0 citations
Despite advances in current therapeutic strategies, osteosarcoma remains a highly aggressive malignancy with limited treatment options. Rutaecarpine (Rut), an indolopyridoquinazolinone alkaloid with selective cyclooxygenase-2 inhibitory activity, has been reported to possess diverse pharmacological properties; however,...
Hyung-Mun Yun, Kyung-Ran Park· Biochimica et Biophysica Act...· 0 citations
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major limitation to the clinical use of DOX, highlighting the need for effective cardioprotective strategies. Although acteoside (ACT), a natural compound with antioxidant properties, has shown potential cardioprotective effects, its role in DIC, particularly in the r...
Meng Wang, Che Wang, Zhi-Hao Liu et al.· European Journal of Pharmaco...· 0 citations
DMC is identified as a thermosensitive inhibitor of SIRT3 and mechanistic insights into its potential to disrupt mitochondrial homeostasis for targeted cancer therapy are provided.
