Oleuropein regulates neuronal survival and Histone acetylation in Parkinson’s disease: cellular and epigenetic insights

Targeting Klotho Signaling for Neuroprotection in Huntington's Disease: A Comprehensive Review.

Klotho is a promising neurochemical modulator with disease-modifying properties in HD, and its multifunctional protective activities are consistent with important pathological markers of HD, necessitating more preclinical and clinical studies to confirm its translational value.

NAD+ signaling in Parkinson's disease: molecular mechanisms and therapeutic perspectives

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by the progressive loss of dopaminergic neurons in the substantia nigra, accumulation of α-synuclein (α-syn), mitochondrial dysfunction, and neuroinflammation. Nicotinamide adenine dinucleotide (NAD + ), a cruc...

The potential of HDAC inhibitors for Alzheimer's disease.

The chapter provides in-depth information on the role of HDAC inhibitors, which hold significant potential as disease-modifying agents in the treatment of Alzheimer's disease and explores various challenges such as off-target effects, restricted isoform specificity, and inadequate blood-brain barrier permeability.

CARM1 as a therapeutic target: The future of disease-modifying therapies for epilepsy.

Epilepsy is a chronic neurological condition characterised by persistent or recurrent spontaneous seizures caused by aberrant and hyper-synchronisation of neurons. It is one of the leading causes of neurological problems affecting over 50 million people all around the globe, and at present, disease-modifying therapeuti...

Therapeutic potential of apigenin in neurodegenerative diseases and brain health

Neuroinflammatory and molecular pathways in Alzheimer’s disease: mechanistic crosstalk and emerging therapeutic opportunities

Overall, this review makes a case for integrative, pathway-based therapeutic models, and multiple approaches may facilitate for drug development, biomarker identification and patient management in Alzheimer's disease.