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Using Manganese‐Enhanced DCE‐MRI to Assess Blood‐Cerebrospinal Fluid Barrier Transport

C. Perera Zhi-Ping Feng S. Nizari Phillip Muza C. Katsiva T. Kalber M. Lythgoe I. Harrison Daniel J. Stuckey Jack A. Wells
Jul 2026 · Magnetic Resonance in Medicine · Vol 96, pp. 2083 - 2091 · 0 citations · 37 references
Medicine

Abstract

We developed a dynamic, heavily T2‐weighted (hT2w) FLAIR protocol to resolve acute Mn2+ transport kinetics, as a proxy for Ca2+, across the choroid plexus (ChP)—cerebrospinal fluid (CSF) interface, in vivo. By quantifying intercompartmental Mn2+ dynamics, and comparing these with Gd‐DOTA, we sought to characterize blood‐CSF‐barrier (BCSFB)‐mediated tracer transport, combining high in‐plane resolution and 4‐min temporal sampling.

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