Aug 2026· Diabetes, obesity and metabolism· Vol 28, pp. 10603 - 10614· 0 citations· 63 references
Medicine
TL;DR
The metabolic phenotypes were explored in a primary care T2DM cohort, supporting their reproducibility across clinical settings and vitamin D status varied by phenotype severity, with more severe phenotypes more likely to exhibit insufficiency.
Abstract
This study aimed to perform an exploratory characterisation of metabolic phenotypes in primary care patients with type 2 diabetes mellitus (T2DM), using a predefined approach and examine their association with vitamin D status.
Biochemical parameters differed across BMI categories, highlighting the role of adiposity in metabolic risk and suggesting that BMI-based stratification may be more informative than diet quality alone.
Cemaliye Süt Kurt, N. Hürer, Rojina Deniz Aygül Elma et al.· Asia Pacific Journal of Clin...· 0 citations
Findings support an association, rather than a causal or diagnostic relationship, between 25(OH)D, chemerin, and cardiometabolic disturbance in this cohort and reveal that diabetic status and female sex were independently related to 25(OH)D status.
M. Baig, Z. Gazzaz, M. Khabaz et al.· Frontiers in Medicine· 0 citations
This study identified and temporally validated key metabolic and clinical markers associated with prevalent T2D in obese Indians using age- and sex-matched case-control analysis and demonstrated good discrimination in obese Indian individuals.
Anagha Vyawahare, Pramod Tripathi, Nidhi Kadam et al.· Frontiers in Clinical Diabet...· 0 citations
In adults with well-controlled T2DM, a more proinflammatory diet is associated with higher systemic inflammation, particularly elevated IL 6 levels, which suggest that dietary inflammatory potential may contribute to residual cardiometabolic risk beyond glycemic control.
B. Calıkoglu, Fatma Yiğiyoğlu Tümer, H. Hacisahinogullari et al.· Journal of Istanbul Faculty...· 0 citations
The findings suggest that the TyG index and vitamin D status are associated with cardiometabolic risk factors; however, the cross-sectional design precludes causal inference, and prospective studies are needed to confirm these associations.
Sweety Kumari, A. Batta, Manju Sharma et al.· International Journal of Hea...· 0 citations
Vitamin D deficiency is associated with an unfavorable cardiometabolic profile characterized by increased adiposity, insulin resistance, inflammation, and a higher prevalence of CVD and should be considered in preventive and clinical risk assessment strategies.
Maria Nikolova, A. Alakidi, R. Tafradjiiska-Hadjiolova et al.· Pharmacia· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.