Cancer remains among the leading causes of death worldwide, with an estimated 20 million new cases and nearly 10 million deaths in 2022 and a burden projected to grow substantially over the coming decades [1]. The conceptual framework of cancer as a disease of dysregulated hallmark capabilities, sustained proliferation...
Ximena Maria Mureșan, Adrian Bogdan Tigu, Andrei Roman et al.· Frontiers in Pharmacology· 0 citations
Chronic hepatitis B virus (HBV) infection remains a major global health challenge, affecting over 250 million individuals and causing more than one million deaths annually from cirrhosis and hepatocellular carcinoma. Although current antiviral therapies effectively suppress viral replication, they rarely achieve a func...
Saniya Sanjaysinh Patil, Siddhi Shivaji Powar, Shruti Vilas Patil, Prathamesh Pundlik Khade· Zenodo (CERN European Organi...· 0 citations
This review dissects tobamovirus genome biology, and highlights the epidemiology of the emerging ToBRFV as a case study, along with an overview of detection and surveillance tools for tobamoviruses.
While previous reviews have largely focused on individual crops or single target-site mechanisms, the full-chain comparative landscape across major cereal crops remains unexplored. Here, we fill this critical gap by providing the first systematic, cross-crop comparative review that spans herbicide targets, resistance m...
Yong-Chao Guo, Xue-Xia Ma, Zi-Hang Li et al.· Plants· 0 citations
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Findings indicate that Rhbg is not essential for spermatogenesis or male fertility in mice, but its absence causes minor, context-dependent alterations in sperm trajectory efficiency during capacitation without affecting core motility or ultrastructural integrity.
Guang-Qing Tan, Lu-Jie Chen, Ru-Xiang Yang et al.· Asian Journal of Andrology· 0 citations
Chronic HBV won't be resolved in the immediate future. Almost 300 million individuals live with it [1], as well as it causes roughly 820,000 deaths annually [1]—mainly due to conditions such as cirrhosis, liver failure, or liver cancer. The usual therapies, such as nucleos(t)ide analogues and pegylated interferon-alpha...
Ponuku Sandhya, Guduri Sathwika, Nuli Sai Vasavi Taruni, S.V. Saikumar· Zenodo (CERN European Organi...· 0 citations
The functional interpretation of infrequent somatic variants remains a challenge in cancer genomics. We developed CRISPR-VUS, a computational framework using public Cancer Dependency Map data to identify Dependency-Associated Mutations (DAMs) - somatic variants associated with increased dependency on their host genes -...
Despite remarkable progress in prevention and treatment, hepatitis is still one of the main drivers of chronic liver disease, liver cirrhosis and hepatocellular carcinoma and is a big public health problem worldwide. The hepatitis viruses A, B, C, D and E are responsible for the occurrence of viral hepatitis in million...
Bhushan H. Jogawe, Unnati K. Bhagade, Suraj D. Thakare· Zenodo (CERN European Organi...· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
This study examines public attitudes toward gene-edited foods in Japan, focusing on how underlying worldviews shape these responses. Drawing on a national survey and a latent class segmentation model based on 23 worldview variables, we identify four distinct segments: Communitarian, Environmentalist, Governmentalist, a...
Tomiko Yamaguchi, Ildeung Na· Public Understanding of Scie...· 0 citations
The CRISPR-Cas9 system revolutionized genome editing and is a very promising platform for the treatment of cancers, genetic disorders, and infections. Yet the clinical translation of CRISPR-Cas9 is hampered by some major bottlenecks related to delivery issues, such as fast degradation, poor cellular uptake, and immunog...
Tushar Ingle Shubhangi Lal· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
