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1,701 papers
Clinical guidelines, including China-specific recommendations, support the use of PCSK9 inhibitors to lower LDL-C and further reduce CV risk for patients with very-high-risk or high-risk ASCVD.
Overall, CRISPR-Cas9 represents a vital platform for future pharmacological innovation, but its broad clinical use may require further validation of safety, efficacy, durability, and accessibility.
This review highlights how plant defense signaling and transcriptional regulation against aphids can be harnessed to develop sustainable and novel pest management solutions.
Background: Hepatocellular carcinoma (HCC) is the predominant histological subtype of primary liver cancer, and many patients with unresectable disease require systemic therapy. This narrative review asks how current systemic regimens should be selected and sequenced, how oncogenic pathways inform resistance and biomar...
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While multi-agent LLM pipelines show real promise for legacy code specifically, since their capacity for autonomous context reconstruction and iterative, feedback-driven refinement directly addresses the sparse documentation and thin test coverage that define legacy environments, the literature to date has been validat...
The findings suggest that AI-powered anomaly detection significantly strengthens observability and security in cloud-based applications, enabling proactive threat mitigation and operational optimization in increasingly complex distributed environments.
It is demonstrated that BcNCED3 positively regulates thermotolerance in non-heading Chinese cabbage and provide a genetic resource for heat-tolerance breeding.
The results indicate that GmSHMT05 sustains overall soybean growth and development in the absence of GmSHMT08, however, GmSHMT08’s gain-of-function in SCN resistance negatively influences pod and root growth, highlighting a potential trade-off between soybean defense and development that may impact yield.
These agents have expanded treatment options for patients with familial dyslipidaemia, severe hypertriglyceridaemia, and persistent residual cardiovascular risk while paving the way for precision medicine.
A comparative model explaining when and why subventral and dorsal glands exchange, retain, or alternate their functions across contrasting parasitic lifestyles across contrasting parasitic lifestyles is explained.
This work proposes LumiCharge, a novel atomic charge prediction framework that incorporates high-order spherical harmonics convolutions and explicitly models multibody interactions, and demonstrates exceptional extrapolation capability and robustness across molecules of varying sizes, effectively overcoming the limitat...
LT16 outperformed existing antiandrogens by fully antagonizing clinical AR mutations and effectively suppressing castration- and enzalutamide-resistant LNCaP cells proliferation in vitro and in vivo, positioning it as a promising and innovative therapeutic for advanced PCa.
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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