Enhancing plant immunity often improves resistance to pathogens, yet its consequences for beneficial symbionts remain underexplored. Here, we assessed the effects of disrupting GmLOPP, a soybean type 2 C protein phosphatase, on both immune activation and rhizobial symbiosis. Loss-of-function Gmlopp mutants displayed en...
Zhixuan Wu, Yuchen Wang, Qinghong Li et al.· BMC Plant Biology· 0 citations
CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing---Cas9's programmable double-strand cuts, the Cas12 and Cas13 families' extensions, and prime editin...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
Description Thalassemia as a Genetic Disorder: From β-Globin Mutation to Precision Prevention and Gene-Based Therapy is an evidence-informed international review that provides a comprehensive overview of thalassemia as an inherited genetic disorder, with particular emphasis on the molecular basis of disease, β-globin g...
Dr.Zeeshan Qaiser· Zenodo (CERN European Organi...· 0 citations
Powdery mildew is a group of plant diseases caused by fungi of the Erysiphaceae family and threatening virtually all important crop plants. The main causative agents of powdery mildew in tomato are the fungi Leveilula taurica and Erysiphe neolycopersici . The genetic basis of tomato resistance to powdery mildew include...
Alexandr Pozharskiy, Valeriya Kostyukova, Ruslan Kalendar et al.· Heliyon· 0 citations
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In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.
Hao Li, Leyi Mei, Jing-Mei Cha et al.· Cell Death & Disease· 0 citations
Supplemental data failes to accompany the dissertation titled "The Evolution of Crucial Verterbate Muscle Proteins." Descriptions of files are provided below. Data S1: Myosin expression values and sample metadata from publicly available datasets. The file does not contain Lonchura striata expression data. NCBI accessio...
Christina M Harvey· Zenodo (CERN European Organi...· 0 citations
Supplemental data failes to accompany the dissertation titled "The Evolution of Crucial Verterbate Muscle Proteins." Descriptions of files are provided below. Data S1: Myosin expression values and sample metadata from publicly available datasets. The file does not contain Lonchura striata expression data. NCBI accessio...
Christina M Harvey· Zenodo (CERN European Organi...· 0 citations
It is demonstrated in vitro that CRISPR can be used to excise the HTLV-1 genome and reduce proviral loads in PBMCs from HAM/TSP patients and may serve as a platform for curing HAM/TSP.
Samuel Brancazio, K. Khalili, Steven Jacobson et al.· Journal of Neurovirology· 0 citations
A programmable gene replacement tool, named prime assembly (PA), which adapts prime editors to produce one or two pairs of 3'-flaps on both the genome and donor DNA, allowing megabase-scale genomic excision and/or kilobase-scale donor insertion at the gene of interest.
Hojun Jung, Bada Jeong, Yong-Woo Kim et al.· Nature Biotechnology· 2 citations· ⚡1
This work proposes that phytomelatonin functions as an epigenetic and epitranscriptomic trigger capable of converting transient stress perception into durable transcriptional competence and outlines how single-cell multi-omics, targeted epigenome editing, epitranscriptomic profiling and field-scale validation of primin...
Chen-Hui Li, Wen-Fang Guo, Xiaofeng Su et al.· Plant physiology and biochem...· 0 citations
This review examines how different types of ncRNAs contribute to cancer initiation, progression, and treatment resistance, and assesses their potential as diagnostic markers, prognostic factors, and therapeutic targets.
Akanksha Samuel, G. Calin· Carcinogenesis· 0 citations
Functional evidence is provided to fine-tune the classification of these SAMD9L variants and significantly advance the understanding of the molecular mechanisms by which SAMD9L variants drive inherited myeloid neoplasms.
E. Vuelta, A. Liquori, M. Morín et al.· British Journal of Haematolo...· 0 citations
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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