Crop genomics has been based on single reference genomes for over last two decades, which have been used for the development of markers, genome-wide association studies and genomic selection, but which have underrepresented structural variation, gene content and haplotype diversity within species.This review explores t...
Unknown authors· Plant and Crop Letters· 0 citations
Genome-editing technologies based on bacterial Cas9 proteins have become a gold standard for introducing precise genetic modifications across multiple species and experimental models. These tools require the design and validation of guide RNAs (gRNAs) that direct the Cas9 protein to the actual genome location to be edi...
Florence Jaouen, Catherine Lépolard, Thomas Bescond et al.· Scientific Reports· 0 citations
The ethics of germline gene editing are discussed in this Viewpoint regarding 3 applications: basic science, treatment and prevention, and enhancement.
Emily P. Dawson, L. Ross· Journal of the American Medi...· 0 citations
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate...
Diana Maltseva, A. Tonevitsky· Frontiers in Molecular Biosc...· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
For more than four decades, islet encapsulation has been defined by a single objective: to immunoprotect transplanted cells while preserving glucose sensing and insulin delivery, thereby eliminating systemic immunosuppression. No passive device has yet achieved that objective with reproducible, durable and clinically m...
A. Citro, Lorenzo Piemonti· Frontiers in Bioengineering...· 0 citations
Pharmaceutical discovery and development continue to be some of the most intricate, financially demanding, and protracted pursuits in the biomedical field, with typical development periods surpassing ten years and failure rates resulting in just a minor percentage of candidates attaining approval. In the last twenty ye...
Sanmay Yadav*, Abhishek Doshi, Sarthak Kole, Mayuri Kore, Sneha Dhekane· International Journal of Med...· 0 citations
This article examines early drug development through the lens of regulatory affairs and project management, with emphasis on readiness for Pre-IND meetings and the IND application for FDA. Sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT) are inherited blood disorders that have long needed dura...
Glutamate receptors constitute one of the most structurally diverse and functionally versatile families of signaling proteins in the animal kingdom, mediating the primary excitatory neurotransmission in the vertebrate central nervous system while also fulfilling ancestral roles in metabolic coordination, osmotic regula...
T. Olivares-Bañuelos, Natalia Morales-Ramírez, Bolaji Oyetayo et al.· Receptors· 0 citations
R analysis code, preregistered decision rules, result files, run logs and figures for a study of what omitting tumor proliferation does to prognostic gene expression estimates. For every expressed gene in a cohort, two Cox models are fitted for overall survival, one adjusted for age, sex and anatomic extent and one tha...
Soon Woo Nam· Zenodo (CERN European Organi...· 0 citations
Spatial transcriptomics links gene expression to tissue structure, yet current models learn embeddings whose meaning is assigned afterwards or read histology without measured expression. Tissue decisions are therefore rarely made from morphology, genes and neighbourhood together, or examined through them. Here we intro...
Tumor organoids are three-dimensional (3D), self-organizing cultures that have become a central experimental platform in cancer research and translational medicine. Their value lies in preserving genetic heterogeneity, reproducing patient-specific phenotypes, and supporting functional drug sensitivity testing. Yet co...
Wen-Wen Zhao, Ling Huang, Yi-Yung Cheng et al.· Journal of Translational Med...· 0 citations
Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a promising therapy option for a variety of malignant and nonmalignant diseases. Given their increased risk to develop certain cancer types, namely lymphoma, and the current progress with HIVenv-directed...
Lea-Isabell Schwarze, Niklas Nuppenau, J. Müller et al.· Human Gene Therapy· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
