gene editing

Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis.

Using this mouse model, it is demonstrated that sFLT1 alone is sufficient for developmental vasculogenesis, whereas the specific loss of flFLT1 enhances reparative revascularization and angiogenesis and improves cardiac recovery after myocardial infarction.

Progress in polymeric nanoparticle-based treatment approaches for Wnt β-catenin pathway modulation and adenomatous polyposis coli mutant colorectal cancer.

About 80-90% of sporadic instances of colorectal cancer (CRC) are caused by mutations in the adenomatous polyposis coli (APC) gene, which is one of the earliest and most common molecular events. The constitutive activation of the Wnt/β-catenin signalling pathway caused by APC dysfunction promotes unchecked cellular pro...

Molecular dynamics simulation and QM/MM study of IscB-ωRNA complex.

The CRISPR-Cas9 system's gene-editing fidelity relies on the HNH nuclease domain's ability to hydrolyze DNA via metal-ion catalysis. While IscB-ωRNA variants offer advantages for viral delivery due to their small size, their editing efficiency is much lower than that of Cas9. The understanding of how HNH-domain dynamic...

Are We Measuring Scientific Intelligence? Rethinking the Evaluation of AI Scientists

AI agents can now carry out data-driven scientific analyses end to end, and benchmarks assess them by giving an agent a question and a dataset and scoring its final answer against a fixed key. These benchmarks assume that a correct answer was derived from the supplied data, a property we call evidence grounding. Howeve...

Anthropic's discovery will, at best, be just another gene-editing tool

Programs and models for incentivizing biotechnology development in medical manufacturing: foreign experience

The presented international experience can establish a foundation for an effective response to the main challenges hindering biotechnology development in Russia, however, achieving maximum efficacy will require adaptation of these tools to the specific economic and legal realities of the Russian Federation.

Sex-specific differences in ADAR editing patterns in response to SARS-CoV-2 infections

ADAR editing is established as an additional layer of immune regulation that may be contributing, in part, to the differential clinical manifestations of COVID-19 observed between males and females.

A comprehensive review of oil biosynthesis pathways and integrated breeding interventions in sesame for nutritional enhancement

Sesame (Sesamum indicum L.) is an important oilseed crop valued for its high oil content and beneficial unsaturated fatty acids. However, low yield, susceptibility to biotic and abiotic stresses, and capsule shattering during mechanized harvesting limit its productivity. Indigenous landraces, particularly in sub-Sahara...

Task-based teaching of genetic engineering-related vocabulary to medical students in ESP classes: a linguodidactic approach

The rapid development of genetic engineering, gene therapy, genome editing, and molecular medicine has increased the need for medical students to acquire specialized English vocabulary in these fields. This article examines the linguodidactic foundations of teaching genetic engineering-related terminology within Englis...

The Genomic Revolution: Breeding Resilient Livestock for a Changing World

The livestock sector is currently under intense pressure to meet a surging global demand for animal products while simultaneously improving animal health and reducing its environmental footprint (Liu, 2026; Wang, 2024). This dual challenge has pushed the industry beyond traditional phenotypic selection toward a "system...

The Genomic Revolution: Breeding Resilient Livestock for a Changing World

The livestock sector is currently under intense pressure to meet a surging global demand for animal products while simultaneously improving animal health and reducing its environmental footprint (Liu, 2026; Wang, 2024). This dual challenge has pushed the industry beyond traditional phenotypic selection toward a "system...

Task-based teaching of genetic engineering-related vocabulary to medical students in ESP classes: a linguodidactic approach

The rapid development of genetic engineering, gene therapy, genome editing, and molecular medicine has increased the need for medical students to acquire specialized English vocabulary in these fields. This article examines the linguodidactic foundations of teaching genetic engineering-related terminology within Englis...