N
6
-methyladenosine (m
6
A) is the most abundant internal modification of eukaryotic mRNA and is dynamically regulated by three classes of proteins: writers, erasers, and readers. Writers deposit methylation marks, erasers confer reversibility, and readers translate these signals into specific regulatory outcome...
Jun Zhang, Sai-Nan Jiang, Jie Yang et al.· Frontiers in Plant Science· 0 citations
The CRISPR-Cas9 system's gene-editing fidelity relies on the HNH nuclease domain's ability to hydrolyze DNA via metal-ion catalysis. While IscB-ωRNA variants offer advantages for viral delivery due to their small size, their editing efficiency is much lower than Cas9. The understanding of how HNH-domain dynamics and me...
Ganggang Bai, Buyong Ma, Jingjing Li et al.· AIP Publishing· 0 citations
The apolipoprotein B mRNA-editing catalytic polypeptide-like (APOBEC) family comprises ten cytidine deaminases implicated in cancer mutagenesis, yet their broader biological significance remains incompletely understood. We performed an integrated pan-cancer analysis of all ten APOBEC family members across 9653 tumors f...
Sairos Ghniem, I. Georgakopoulos-Soares, A. Zaravinos· International Journal of Mol...· 0 citations
Imagine being able to find a particular spelling mistake in the enormous instruction manual of life and correct it. This is the basic idea behind one of the most exciting technologies in modern biology: CRISPR-Cas gene editing. Our DNA contains the genetic instructions that control how cells develop and function. Chang...
Priyanka Malakar and Kanchan Singh· Zenodo (CERN European Organi...· 0 citations
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In June 2026, satri-cel/CT041, a chimeric antigen receptor (CAR) T-cell product targeting Claudin18.2, received approval from China’s National Medical Products Administration for the treatment of Claudin18.2-positive, HER2-negative advanced gastric/gastroesophageal junction adenocarcinoma after failure of at least tw...
Li-Ping Zeng, Sheng Wei, Nan Chen et al.· Frontiers in Immunology· 0 citations
Reproducibility archive for the study “Adult heart failure molecular anchoring and functional mapping diverge across cardiac systems.” This v1.0.1 package contains original figure-generation scripts, derived figure-source tables, and final PNG/SVG exports for Main Figures 1–5 and Supplementary Figures S1–S8, together w...
Zisen Zhou· Zenodo (CERN European Organi...· 0 citations
Plant mitochondrial genomes are structurally dynamic and contribute to energy metabolism and stress responses. Comparative mitogenomic analyses of closely related species occupying contrasting elevations can provide insights into mitochondrial genomic differentiation across elevational environments. Using PacBio HiFi...
Ya-Li Wang, Jian-Li Zhao· Frontiers in Plant Science· 0 citations
Since plants are constantly exposed to ever-changing climate conditions, they evolved an intricate system that perceives environmental stresses and integrates them in order to adapt their response. At a molecular level, transcription factors play an important role in regulating the plant’s response by influencing e...
M. Ferrero, Maria Pane, Alex Maioli et al.· Plant growth regulation (Pri...· 0 citations
Conventional and transgenic approaches to crop improvement are increasingly constrained by biosafety concerns, stringent regulatory frameworks, and limited public acceptance, necessitating new precision breeding methods. DNA-free genome editing using the CRISPR/Cas9 approach has emerged as a transformative approach t...
Roshini Senthilkumar, Rakshana Palaniswamy, Sakthi Ambothi Rathnasamy et al.· Frontiers in Plant Science· 0 citations
Dataset Description This repository contains the synthetic genomic workflow dataset generated and used for the experimental evaluation of the PRIVAGEN-SHIELD framework, “PRIVAGEN-SHIELD: Privacy-Preserving Genomic Anomaly Detection via Hierarchical Blockchain-Authenticated Merkle Trees and Local Differential Privacy.”...
R. Kannadasan, C Prabakaran· Zenodo (CERN European Organi...· 0 citations
Protein stability, the capacity to maintain a folded structure and function, matters as much for transporters and regulators as for enzymes, and heat erodes it. Wheat, rice, maize and soybean supply two-thirds of human caloric intake, and warming reduces yields. Rubisco activase variants selected for thermostability in...
Sensing of pathogen-associated molecular patterns (PAMPs) is a critical step in mounting effective immune responses against invading pathogens. Toll-like receptor 5 (TLR5) is central to this process through its recognition of bacterial flagellin. While the function of the canonical membrane-bound form (TLR5M) appears c...
Andrew T. Wood, Aaron J. Smith, Max Charles Vallarino et al.· Fish and Shellfish Immunolog...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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