Saccharomyces cerevisiae is a widely used industrial chassis for the heterologous biosynthesis of natural products. However, achieving high-level expression of heterologous genes and developing efficient metabolic engineering strategies remain major challenges. Here, based on the polycistronic expression system and the...
Sisheng Zhang, Jingyi Chen, Yang Yang et al.· Microbial Cell Factories· 0 citations
Phellinus species are well-known white-rot fungi belonging to the Hymenochaetaceae family. Phellinus species contain medicinally functional compounds and nutrients. However, a comprehensive genus-level analysis of their mitochondrial genomes remains unavailable to date. The complete mitochondrial genome of P. tuberculo...
Can Jin, Mu-Xi Yuan, Jin-Xin Ma et al.· BMC Genomics· 0 citations
Background/Objectives: Plant mitochondrial genomes are structurally dynamic, and assembled paths may not reflect all molecular configurations. We characterized the mitochondrial genome of Rhododendron spinuliferum and evaluated repeat-associated structural heterogeneity and transcript support for mitochondrial RNA proc...
Jie Chen, Yikai Feng, Xinyi Qian et al.· Genes· 0 citations
A complex biological mechanism, ageing is the gradual decline in tissue utilisation and restoration of functions. Recent studies show that ageing can be slowed down or reversed with the application of pro-regenerative machinery. Of critical healing processes evaluated in this study, immune modulation, stem cell and cel...
L. Durga, Sridevi Gopathy, A. Arockya Stafi et al.· Regeneration· 0 citations
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Gene replacement and gene editing therapies for cardiomyopathies are in early-phase clinical trials. However, limited data exist on patient perspectives. We assessed adult familial cardiomyopathy patient perspectives towards the clinical implementation of somatic genetic therapies. Patients completed a demographic surv...
Anjali Narain, Kayla Ruiz, Matthew T. Wheeler et al.· BMC Medical Genomics· 0 citations
Abstract Background: CRISPR platforms could modify molecular causes of neurological disease and engineer cells used in neurosurgical treatment. Their clinical value depends on disease mechanism, editing modality, anatomical delivery and the capacity of surviving neural circuits to recover.Objective: To assess CRISPR th...
Gandhi Bhaskar Patrudu Lanka· Zenodo (CERN European Organi...· 0 citations
Compared to other nucleotides, cytosines occupy a unique regulatory position in plant genomes through methylation-based epigenetic control. Measuring the influence level of each cytosine on downstream gene’s expression is a highly promising question which would result in precise control intervention which still remains...
Veerbhan Kesarwani, Anchit Kumar, Akanksha Sharma et al.· Zenodo (CERN European Organi...· 0 citations
Rhizopus species are a leading cause of mucormycosis, an aggressive and life-threatening invasive fungal disease that affects immunocompromised individuals. Despite their clinical importance, mucoralean pathogens, especially R. delemar, are difficult to manipulate genetically because of coenocytic growth, multinucleate...
Andrew Terrebonne, Muxing Liu, Ryan Rumsey et al.· Journal of Fungi· 0 citations
Colorectal cancer (CRC) is one of the most prevalent malignancies of the gastrointestinal tract worldwide. Notably, most patients with microsatellite-stable (MSS) tumors show primary resistance to immune checkpoint inhibitors (ICIs), creating an unmet clinical need. The mechanisms underlying immune evasion and strategi...
Da Ding, Jingyi Hu, Yitong Wang et al.· International Journal of Mol...· 0 citations
IntroductionIn February 2025, a single infant with carbamoyl phosphate synthetase 1 deficiency received a customized base-editing therapy, and individualized gene editing has since been discussed as an emerging category of care.No one has yet counted whether this category exists in the registered study record. MethodsW...
Oscar Mingtian Li, Yijiang Li· Cureus· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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